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What Are GLP-1RAs, and How Do They Work

Discontinuation studies show that patients typically regain a substantial portion of lost weight within one year of stopping medication, accompanied by return of appetite and metabolic parameters toward baseline

At 50 mg to 200 mg per dose, the high injection volume requires intramuscular (IM) administration or splitting the dose across multiple subcutaneous sites

In weight loss clinical trials, semaglutide helped people lose about 15 percent of their body weight on average significantly more than the currently available obesity drugs and more than enough to improve health outcomes