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In elegant experiments, Perley and Kipnis in 1964 demonstrated that gastrointestinal, endocrine factors were responsible for the augmented insulin secretion (7) and also demonstrated that this mechanism was greatly impaired in non-insulin requiring maturity onset diabetes. The question then arose, which factors might be responsible, and the interest again turned toward the gastrointestinal hormones

Most people notice cumulative benefits after four to eight weeks of consistent use, provided the supplement is in a highly bioavailable form

2006 Jun 1;73(11):1981-90