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Non-human primates (rhesus (Twaddle et al., 2019) and cynomolgus monkeys (Shen et al., 2021)) have metabolic similarities to human especially for CYPs (Uno et al., 2018), and the chimpanzee has been characterized as a surrogate for drug oxidation and glucuronidation in humans and as a PK model for the selection of drug candidates (Yang et al., 2014)

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TOP Folate Testing Serum folate and red blood cell (RBC) folate testing is no longer offered in BC

Methylation of either of the nitrogen atoms in the imidazole rings of the histidine residues 6, 13 and 14 prevents formation of bridging histidine moieties