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Consequently, this comprehensive review sought (i) to investigate the existing research regarding the effects of GLP-1Ra on bone metabolism, encompassing both preclinical studies and human trials and (ii) the current knowledge related to the impact on bone metabolism of weight loss following calorie restriction and metabolic/bariatric surgery

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However, phase III research clinical studies are still pending to evaluate the effect of retatrutide in weight management and its impact on weight-related health issues such as obstructive sleep apnea, osteoarthritis, and non-alcoholic fatty liver disease (NAFLD)