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marketed as Mounjaro for T2DM and Zepbound for obesity), is a 39-amino acid peptide acylated with a C20:0 fatty diacid moiety to lysine residue at position 20 with a molecular weight of 4.8 kDa [ Figure 2 , Table 1 ]

It is a hormone classified as an incretin , meaning it is released by the gut in response to food intake and stimulates insulin secretion

Clinicians soon noticed that many patients experienced substantial weight loss, often without intentional dietary changes

Large meals, fried foods, alcohol, and spicy foods can make these symptoms worse, while smaller portions and simpler, easy-to-digest meals are often better tolerated