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Dizziness Weakness Drowsiness or fatigue Slow heartbeat Low blood pressure Dry mouth, skin, or eyes Headache Upset stomach Diarrhea or constipation Heart block Cold hands and feet Weight gain Less common side effects include: Depression Shortness of breath, wheezing, or trouble breathing, with people who have asthma or Raynauds syndrome facing a higher risk of these adverse effects High blood sugar (hyperglycemia) Trouble sleeping, including insomnia and nightmares Swelling of the hands or feet (edema), specifically in those who take carvedilol (Coreg) Sexual and erectile dysfunction Are There Any Risks

As for effectiveness, the skin has different characteristics in different places, all of which impact drug potency

A lower-carbohydrate, higher-fat diet reduces abdominal and intermuscular fat and increases insulin sensitivity in adults at risk of type 2 diabetes