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There's no margin for approximation

As a result, herein, we review the synthetic and metabolic processes of GSH, systematically describing the functions of the GSH system in cardiac injury

Thus, while we were not successful in obtaining more reactive analogs at this point, this approach allows us to explain the observed low reactivity at physiological pH and offers a valuable tool for guiding the future design of nucleotide-based inhibitors with optimized preorientation and reactivity profiles, providing a systematic framework for enhancing these compounds reactivities in a targeted manner