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Limited Human Reports A small number of human publications exist, but their scale and design do not establish general safety or effectiveness

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A 2025 University of Virginia study concluded that while GLP-1 drugs significantly reduce body weight and adiposity, they do so "with no clear evidence of cardiorespiratory fitness enhancement"a critical finding given that cardiorespiratory fitness is among the most potent predictors of all-cause and cardiovascular mortality [48]

(19) A Word about Skin Lightening Glutathione also has a reputation as a skin lightening agent, with fans claiming that it reduces dullness, dark spots, and discoloration, promoting an even skin tone