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The applicant stated that the aprevo insertion instrument is an FDA class II instrument integral to the device systems and that other commercially available inserters are not FDA-authorized for use with or compatible with the aprevo Cervical ACDF System

Die Substanz wurde dann nicht weiterentwickelt nicht wegen Sicherheitsproblemen, sondern weil das ursprnglich avisierte Indikationsgebiet (postoperativer Ileus) eine eingeschrnkte Marktgre hatte

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The test compound was pre-incubated with purified human recombinant cyclooxygenase 1 (COX-1) or cyclooxygenase 2 (COX-2) (Cayman Chemical) for 15 min