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For comparison, the American Diabetes Association considers a one percentage point A1C reduction clinically meaningful

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The 2022 ACC guidelines recommend PCSK9 inhibitors and bempedoic acid based on a patients ASCVD risk and LDL cholesterol levels, particularly those with established CVD, high cardiovascular risk, or in patients who do not achieve LDL-C targets with maximally tolerated statin and ezetimibe therapy, or who are statin-intolerant [166]