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Although some individuals may report positive effects anecdotally, these personal accounts do not replace medical evidence

Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction

Metabolic issues: Feeling constantly cold, chills, or a low body temperature (signs of metabolic acidosis) Severe gastrointestinal changes: Persistent diarrhea, vomiting, or a total loss of appetite Systemic changes: Unexplained tiredness, a fever or other signs of infection, unusual bleeding, bruising, or long-term concerns like osteoporosis In general, higher doses of topiramate are associated with an increased risk of adverse reactions

The original work was on ubiquinone and thats what you were turning around heart failure patients with