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Therefore, GLP-1RAs that mimic the function of native GLP-1 but with improved pharmacokinetics are highly desirable as drug candidates for the management of T2DM (Prajapati et al., 2024)

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Several subsequent animal studies using different illnesses models revealed a consistent upregulation of iodothyronine deiodinase 2 (D2) both in the PVN and in tanycytes, suggesting an increase in local T 3 production, which helped explain the abnormal negative feedback resulting in TRH downregulation besides low levels of serum T 3 (65, 66)

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