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On the other hand, the hormone status and other metabolites levels, such as serum 25(OH)D in women younger than 30 years, are lower than that in women 30 years and older (Reference Nakamura, Nashimoto and Matsuyama45)

But side effects, including nausea, vomiting, diarrhea and constipation, affect roughly 50% to 60% of patients, typically diminishing over time, according to Science Direct

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Developmental abnormalities Reduced sperm quality in diabetic men, particularly increased DNA fragmentation and morphological abnormalities, may impair fertilization and embryonic development, thereby increasing the risk of miscarriage, premature birth, and congenital anomalies [38, 44, 100, 101]