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The perfusion of 5-fluorouracil (5-FU), a common chemotherapeutic agent, through the vascular channel of the device, consistently exhibited expected hematotoxicity at clinically relevant low micromolar concentrations across six donors of CD34 + progenitor cells, demonstrating the reliability and relevance for toxicity testing

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GSH levels naturally decline with age and are depleted by alcohol, intense training, certain medications, and chronic inflammatory states