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When A Discovery Is Made, Pharmaceutical Companies Step In Building on this early work, Novo Nordisk developed, patented and secured FDA approval for two GLP-1 drugs to treat Type 2 diabetes: liraglutide and, a few years later, semaglutide

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Furthermore, studies have shown that the FA metabolites in neutrophils play a chemotactic role in the infiltration of neutrophils into the inflammatory sites, with AA metabolism playing a dominant role (69, 70) Multiple clinical studies have revealed that patients with GA exhibit abnormal AA metabolism, significantly elevated 5-LOX transcription levels, and abnormal increases in LTB4 production, which acts as a neutrophil chemotactic factor (7173)