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The once-prevailing vascular theory, which posited that headaches stem from dilation of dural and extracranial blood vessels, has been refuted, with such vasodilation now regarded as an effect rather than a cause of migraines (8)

Still, even a well-formulated diet does not guarantee that an older or stressed dog is meeting demand at the cellular level

Genetic redundancy within the pathway Given the genetic complexity of the pathway (Table 1), gene-specific Arabidopsis mutants have been very useful in defining the importance of the different isoforms