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Possible injection site reactions

In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration

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Meanwhile, some preclinical and clinical studies have proved that no significant adverse effects were observed during the TCM treatment period ( TABLE 3 Clinical trials of TCM in AP