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doi: 10.3389/fimmu.2025.1603018 Received 31 March 2025 Accepted 04 July 2025 Published 21 August 2025 Volume 16 - 2025 Edited by Wenlong Wang, Pingdingshan University, China Reviewed by Muthukumar Serva Peddha, Central Food Technological Research Institute (CSIR), India Mahmood Ahmed, University of Education Lahore, Pakistan Lu Wang, Zhejiang Chinese Medical University, China Updates Copyright 2025 El-Saadony, Saad, Mohammed, Alkafaas, Ghosh, Negm, Salem, Fahmy, Mosa, Ibrahim, AbuQamar and El-Tarabily

Thus, it is well-established that increased ROS and MDA levels, or reduced levels of antioxidants like SOD, GPx, and catalase, signify mitochondrial dysfunction and oxidative stress, which is also associated with cognitive impairment

At the standard 25-unit daily dose, that is 1 mg of Tesamorelin per day

Tissue healing, angiogenesis promotion, anti-inflammatory activity, gut protection, neuroprotection the accumulating animal literature continues to be both compelling and mechanistically coherent