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A 2025 Cochrane review of 18 studies confirmed that semaglutide (Wegovy/Ozempic) results in approximately 10.7% greater weight loss compared to placebo, with high-certainty evidence [6]

Activation of Notch signaling and the expression of its downstream target gene, hairy and enhancer of split 1 ( Hes1 ) in TA cells repress the expression of transcription factors crucial for entry into the secretory lineage including atonal homolog 1 ( Atoh1 ) and induce absorptive cell fate commitment

11.Wharton S, Freitas P, Hjelmesth J, et al