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Similar to the previous findings, the light-adapted states of the B 12 -bound Ab Pcob and the holo Sas Pcob (i.e., both AdoCbl and BV bound) activate Ab DGC catalysis
However, human safety data remains limited to anecdotal reports and Phase I/II trial abstracts that never reached full peer-reviewed publication
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It is deliberately membrane-permeable, which is what lets it get inside cells and act on an intracellular enzyme
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