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10.1021/acs.molpharmaceut.2c00261 23 BeutheuS.GhouzaliI.GalasL.DechelotteP.CoeffierM

In a published Phase 2 trial (48 weeks), adults with obesity who took retatrutide lost, on average, more weight at higher doses, with the 12 mg group showing 24.2% average weight change at 48 weeks (compared with 2.1% in the placebo group)

Its not considered addictive like opioids or benzodiazepines, but dependence/withdrawal can occur if stopped abruptlytaper with a clinician

Compounded semaglutide with B12 is prepared by compounding pharmacies, either 503A state-licensed pharmacies that fill individual prescriptions or 503B outsourcing facilities that produce larger batches under federal oversight