Yes, paracetamol is generally the safer first-line choice for pain relief whilst taking Wegovy because it does not irritate the stomach lining or carry the gastrointestinal risks associated with NSAIDs like ibuprofen, making it particularly suitable when experiencing Wegovy-related nausea or gastrointestinal sensitivity
With the advent of larger data sets, Polygenic Risk Scores are getting better and better, particularly at identifying people at the extremes
Mallach et al., 2024), tauopathy (De Strooper and Karran, 2016), lysosomal dysfunction (Nixon and Rubinsztein, 2024), acidification and Ca 2+ dyshomeostasis (LaFerla, 2002), and vasculature damage and angiopathy (Zlokovic, 2011) have been investigated long time
So, its going to be interesting to see what happens