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The dysfunction may not be the same. Endocrine specialist Jody Dushay of Bostons Beth Israel Deaconess Medical Center said that shes also seen people have issues losing weight with GLP-1s though generally, she and her patients are able to tell whether theyre going to work within a few weeks

In gastrointestinal inflammatory conditions , observational data suggest that GLP-1RA use in patients with inflammatory bowel disease is associated with a lower risk of IBD-related surgery in both ulcerative colitis and Crohns disease, and early studies have explored whether GLP-1RA injections can reduce pain in irritable bowel syndrome patients (the answer was yes)

Factors such as severe thrombocytopenia, serum aspartate aminotransferase levels exceeding 60 U/L and the presence of diabetes have been identified as independent predictors associated with pruritus in cirrhosis (21)