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Gastrointestinal adverse events - predominantly nausea, vomiting, diarrhea, and constipation - are the most common class effects, occurring in 20%-60% of patients depending on the agent and dose, and are typically of mild-to-moderate severity, dose-dependent, and most prominent during titration

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nevertheless, they are only found in trace levels

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Toll-like receptor 4 activation increases AKT phosphorylation in colon cancer cells

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