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- Proof of Concept: This is the first clinical evidence of a therapy leading to increased total lung capacity (TLC) and a reduction in radiological fibrosis markers
Journal of Chromatographic Science
Thus, it indicated that the biological effects of TRG may be partly dependent on its ability to regulate ferroptosis
Importantly, the inhibition of BTK and SYK pathways, implicated in the amplification NF-B and MAPK-mediated inflammatory cascades and intersecting with the JAK/STAT network [246, 250], could support a translational link between B-cell-driven inflammation and attenuation of fibrosis in HS lesions
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