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While some doctors have anecdotally reported similarly positive experiences in their patients who switched to a slower schedule, the studys results are limited: The sample size is quite small, for one, and more work in larger and more diverse groups will be needed to understand if different dosing schedules could help more people stay on their medication, without getting the pukes.

Specifically, 33 of 60 (55 %) reported weight loss at some point during treatment

The take home here is that metformin may be a safer drug, but it's not without its risks

Individuals who maintain a healthy lifestyle and consume a well-balanced diet may experience longer-lasting benefits from B12 injections