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In a recent observational study, individuals who discontinued semaglutide or tirzepatide within the first three months lost only 3.6% of their body weight, while those who quit between three and twelve months lost 6.8%

Skin-related reactions are also common, including irritation, redness, itching, or allergic responses from the adhesive or active ingredients in the patch

And because the ATTAIN-MAINTAIN trial just proved something remarkable: people who switched from tirzepatide to orforglipron kept their weight off

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