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These can include nausea, vomiting, diarrhea, constipation, decreased appetite or mild digestive discomfort

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Appetite, fluid retention, and metabolic effects Because MK-677 is a ghrelin-receptor agonist, appetite stimulation is expected, and it was observed: in the two-year healthy-elderly trial, increased appetite was among the most frequent effects, though it tended to subside over a few months