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Since there is no FDA-approved GHK-Cu drug, responsible physicians inform patients about the uncertain evidence

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Small trials suggest potential to reduce cancer-treatment toxicities, but it has not been shown to treat cancer

Thus, to gather additional evidence about the identity of the LDOX oxidation product, we performed enzymatic reactions in buffer containing H 2 18 O, exploiting the expected equilibrium between the gem-diol flavan-3,3,4-triol ( 4 ) and the corresponding ketone flavan-3-on-4-ol ( 7 ) (Fig