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doi: 10.1016/j.bcp.2017.07.010 66 TongBYuJWangTDouYWuXKongLet al

IGF-1 LR3 has a 13-amino acid N-terminal extension plus an arginine substitution at position 3, totaling 83 amino acids

Patients with favorable GLP1R or GIPR predispositions may achieve clinical goals at lower doses and costs, while those with FTO or MC4R variants may require higher doses or dual-agent compoundschanging the true cost-per-outcome calculation significantly

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