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Read review Dihexa for Endometriosis Brain Fog The November 2025 Lancet O&G/WH 'overlooked symptom' commentary from Edinburgh EXPPECT, the April 2025 Horn FACT-Cog 1,239-patient survey (~80% perceived cognitive impairment), the March 2025 NICE TA1057 Ryeqo approval (first daily pill on NHS), the April 2024 NICE NG73 update, the April 2026 renewed Womens Health Strategy with 117 action points, the 2023 Greaves CNS-wide glial activation mouse model, the BDNF/TrkB central-sensitisation directionality paradox, and the ~1.5 million UK women affected

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Systemic administration data argue that the postsynaptic antagonistic effects of NTS1 on D2R function may predominate since brain-penetrating NT analogs given systemically reduce the pharmacological effects of psychostimulants and do not appear to be rewarding (Binder et al., 2005)

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Malonyl-CoA also plays a vital role in PUFA synthesis, where dietary linoleic acid undergoes sequential desaturation and elongation reactions catalyzed by fatty acid desaturase (FADS)2, ELOVL5 and FADS1, leading to the formation of AA (C20:4, -6), which can be further elongated by ELOVL2/4 to generate AdA (C22:4, -6) (76)

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