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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations Angptl4 Angiopoietin-Like 4 bLPL bovine LPL BSA Bovine Serum Albumin CVD cardiovascular disease CXN calnexin EL endothelial lipase ER endoplasmic reticulum fAngptl4 full-length Angptl4 FFA free fatty acids GPIHBP1 glycosylphosphatidylinositol-anchored high-density lipoproteinbinding protein 1 HDX-MS Hydrogen Deuterium Exchange Mass Spectrometry HL hepatic lipase HR heparin release HTG hypertriglyceridemia KRP Krebs Ringer Phosphate LMF1 lipase maturation factor LPL lipoprotein lipase nAngptl4 N-terminal domain Angptl4 PC proprotein convertase PHP post-heparin plasma SorLA sortilin-related receptor with type-A repeats TG triglyceride TRL TG-rich lipoproteins VLDL very-low density lipoproteins

That means a BMI of 30 or higher, or a BMI of 27 or higher plus a weight-related health problem (such as obstructive sleep apnea)

The SELECT cardiovascular outcomes trial demonstrated a 20 percent reduction in major cardiovascular events, suggesting benefits beyond weight loss that may justify long-term use even after weight goals are achieved