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Hypoxia increases the dependence of glioma cells on glutathione
10.1016/j.carbpol.2025.123695 153 WuG.LiuS.WangZ.WangX
In dynamic inhalation exposure studies on guinea-pigs (Waite et al., 1930), rats, mice, and dogs (Jacobson et al., 1956), nasal irritation was the first clinical effect, as evidenced by scratching the nose, nasal discharge, lachrymation, and salivation
Whereas phosphodiesterase-5 (PDE-5) inhibitors like sildenafil and tadalafil operate peripherally increasing blood flow to genital tissue PT-141 bypasses vascular physiology entirely and acts directly on the brain
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