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In contrast, GHK-Cu administered subcutaneously is released into the bloodstream instantly and in a controlled dose, which triggers more than 300 repair-related genes, helps to multiply fibroblast growth and contributes to the longevity of epidermal stem cells located in the basal layer

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Circulation 107:13591365 Yasumura EG, Stilhano RS, Samoto VY, Matsumoto PK, de Carvalho LP, Valero Lapchik VB, Han SW (2012) Treatment of mouse limb ischemia with an integrative hypoxia-responsive vector expressing the vascular endothelial growth factor gene