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The SURMOUNT-1 Phase 3 trial published in The New England Journal of Medicine enrolled 2,539 adults with obesity and demonstrated mean body weight reduction of 20.9% at 72 weeks on tirzepatide 15mg weekly versus 3.1% placebo

These limitations highlight critical research gaps, including the need for prospective studies, multicenter registries, and clinical trials to strengthen the evidence base and refine recommendations for diverse clinical and geographical contexts

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General Timeline for Resuming Semaglutide Your own doctor will tell you the exact right time