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It started affecting all our practices, with our colleagues from anesthesia canceling procedures. She continued: Additionally, this recommendation has a downside for our patients with diabetes: If they hold their medication for a week, they run the risk of developing hyperglycemia. To evaluate the risk for aspiration and other safety concerns associated with GLP-1RAs, Popov and colleagues performed a systematic review and meta-analysis of research that included outcomes of upper endoscopy and colonoscopy among patients using GLP-1RAs