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The TDP-43 Q331K transgenic mice dosed with vehicle showed a gradual decline in rotarod performance over the duration of dosing as expected, however there was no significant difference between liraglutide dosed animals and vehicle dosed animals

They compared people who had begun taking a GLP-1 medication for other reasons, like weight loss, within a year of receiving a diagnosis of chronic migraine to individuals who started taking topiramate during the same period

However its worth looking at some exceptions that help to illustrate the key points here

The stimulus strength that produced a 50% response rate was determined and taken as the withdrawal threshold