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These effects may potentially provide a new therapeutic solution for stroke with specific beneficial effects on the CNS (i.e., reperfusion, amelioration of neuronal damage leading to recovery in the absence of memory, motor, and coordination deficits, and expression of specific genes in the hippocampus)

Concentration-dependent ex vivo permeation is well-documented in the literature [86]

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Therapeutics that target the RAAS appear to be promising to treat LC symptoms