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Semax is formally an analog of the ACTH(4-10) fragment, the active core Met-Glu-His-Phe capped with a stabilizing Pro-Gly-Pro tail that keeps it from being chewed up too fast, and it is stripped of the parent hormones effects on the adrenal glands, so it acts on the brain without the stress-hormone baggage

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Collectively, the results of this study illustrate that AOD9604 exerts distinct metabolic effects depending on the genetic background of the animal and the presence of functional 3-ARs

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