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This clinical guideline from the American College of Gastroenterology provides evidence-based recommendations for the management of IBS-C, which is essential for understanding the current practice strategies and limitations

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In 1978, building on this discovery, Zamecnik and Stephenson 32 used specific oligodeoxynucleotide chains that target the 35S RNA of the Rous sarcoma virus to inhibit virus replication, marking a prototype for the application of antisense oligonucleotide (ASO) drugs in disease treatment