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Research has characterised MT-IIs transient blood pressure and heart rate changes , documenting central autonomic melanocortin receptor-mediated cardiovascular effects following MT-II administration through hypothalamic MC4R activation of sympathoadrenal outflow

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In contrast, melanoma evolution is dominated by whole genome doubling and large-scale aneuploidy, in which widespread loss of heterozygosity sculpts the burden of point mutations, neoantigens and structural variants even in treatment-nave and primary cutaneous melanomas in some patients

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