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The lack of harmonized international standards means a company faces a patchwork of requirements: a nano-formulated vitamin might be freely sold in one country but considered novel in another, requiring extensive approval processes

[DOI] [PMC free article] [PubMed] [Google Scholar] [70].Kang HK, Michaels MA, Berner BR

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In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization