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It is about ensuring that the pathway functions properly

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10.1016/j.biomaterials.2013.07.100 172 ZaakH.BendifH.RebbasK.AouatiL.AbdennourA.HamzaA.et al (2022)

Treatment with febuxostat did not reduce significantly the progression renal disease, with a fall in eGFR in the placebo group of (-0.47 4.48 ml/min/1.73 m2) vs 0.23 5.26 ml/min/1.73 m2 in the febuxostat group